| Caffeine | Depuffing, vasoconstriction, antioxidant | Adenosine receptor antagonist, vasoconstrictor | Fluid puffiness, vascular dark circles, fine lines | Temporary effects; won't treat pigment-based dark circles |
| Vitamin C | Brightening, collagen support | Inhibits melanin synthesis, antioxidant | Pigment-based dark circles, dullness, early fine lines | Unstable in some formulas; can irritate sensitive skin |
| Retinol | Collagen stimulation, cell turnover | Binds retinoic acid receptors | Deep wrinkles, severe collagen loss, skin thinning | Irritating; not suitable for all skin types; avoid around eyes without care |
| Niacinamide | Brightening, barrier repair, anti-inflammatory | Inhibits melanin transfer | All-around under-eye support, dark circles, pores | More modest effect on puffiness specifically |
| Peptides | Collagen stimulation, firmness | Signal skin cells to produce collagen | Wrinkles, loss of firmness, skin thinning | Slower results; needs 12+ weeks |
| Hyaluronic acid | Plumping, hydration | Humectant — attracts water | Dehydration lines, crepiness, surface dryness | Doesn't address puffiness or vascular darkness |
| Vitamin K | Vascular dark circles | Promotes blood coagulation, reduces pooled blood | Blue-toned dark circles | Limited strong clinical evidence |
| Ceramides | Barrier repair, hydration | Replenishes skin lipids | Dry, sensitive, compromised under-eye barrier | No direct effect on puffiness or dark circles |
| Cold compresses | Immediate depuffing | Vasoconstriction via temperature | Acute morning puffiness | Purely temporary, no skincare benefit |
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